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Can Parkinson's disease cause? When dopamine levels decrease, it causes abnormal brain activity, leading to symptoms of Parkinson's disease. The cause of Parkinson's disease is unknown, but several factors appear to play a role, including: Your genes. Researchers have identified specific genetic mutations that can cause Parkinson's disease.
What is the off period in Parkinson's disease? Motor fluctuations are " off " times, when medication — namely levodopa (the "gold standard" treatment for Parkinson's) — is not working optimally and Parkinson's symptoms (motor and/or non-motor) return. " Off " periods are more common as the disease progresses and people take medication for a longer period of time.
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